endopeptidase activity metalloendopeptidase activity https://github.com/geneontology/go-ontology/issues/28557 https://github.com/geneontology/go-ontology/issues/30193 Reactome:R-HSA-5362793 Reactome:R-HSA-5694082 Reactome:R-HSA-194809 Reactome:R-HSA-194808 MetaCyc:3.4.24.18-RXN Reactome:R-HSA-1564179 Reactome:R-HSA-9840408 MetaCyc:3.4.24.24-RXN EC:3.4.24.18 EC:3.4.24.17 EC:3.4.24.19 Reactome:R-HSA-8874192 Reactome:R-HSA-8874195 Reactome:R-HSA-8874194 Reactome:R-HSA-9840532 metalloendoprotease activity Reactome:R-HSA-194818 Reactome:R-HSA-1564169 Reactome:R-HSA-5228578 Reactome:R-HSA-2514831 metalloendoproteinase activity Reactome:R-HSA-1564164 MetaCyc:3.4.24.35-RXN Reactome:R-HSA-3828025 Reactome:R-HSA-9010034 Reactome:R-HSA-1454822 EC:3.4.24.11 EC:3.4.24.14 Reactome:R-HSA-3371385 Reactome:R-HSA-8940641 Reactome:R-HSA-3788075 EC:3.4.24.21 EC:3.4.24.23 EC:3.4.24.22 EC:3.4.24.24 Reactome:R-HSA-1564184 Reactome:R-HSA-4086205 Reactome:R-HSA-177946 MetaCyc:3.4.24.56-RXN Reactome:R-HSA-264758 Reactome:R-HSA-9844241 EC:3.4.24.34 Reactome:R-HSA-2168046 EC:3.4.24.35 EC:3.4.24.37 Reactome:R-HSA-9840564 Reactome:R-HSA-1474196 MetaCyc:3.4.24.70-RXN Reactome:R-HSA-9824402 MetaCyc:3.4.24.17-RXN Reactome:R-HSA-2168982 Reactome:R-HSA-181567 Reactome:R-HSA-8874187 Reactome:R-HSA-1168777 MetaCyc:3.4.24.14-RXN MetaCyc:3.4.24.57-RXN Reactome:R-HSA-1592310 MetaCyc:3.4.24.61-RXN Reactome:R-HSA-2179402 Reactome:R-HSA-6784620 Reactome:R-HSA-1299476 Reactome:R-HSA-2484882 Reactome:R-HSA-1299478 Reactome:R-HSA-8943959 Reactome:R-HSA-2537499 Reactome:R-HSA-8940561 Reactome:R-HSA-8940554 Reactome:R-HSA-9934645 Reactome:R-HSA-3791319 Reactome:R-HSA-3827958 Reactome:R-HSA-8874122 Reactome:R-HSA-2485148 MetaCyc:3.4.24.71-RXN MetaCyc:3.4.24.11-RXN MetaCyc:3.4.24.22-RXN MetaCyc:3.4.24.37-RXN Reactome:R-HSA-9624272 Reactome:R-HSA-8877620 Reactome:R-HSA-2514790 Reactome:R-HSA-2533950 Reactome:R-HSA-2534248 Reactome:R-HSA-2022141 MetaCyc:3.4.24.59-RXN Reactome:R-HSA-2534240 Reactome:R-HSA-5250892 Reactome:R-HSA-1655851 Reactome:R-HSA-381518 Reactome:R-HSA-2533944 MetaCyc:3.4.24.69-RXN Reactome:R-HSA-4224014 Reactome:R-HSA-381435 Reactome:R-HSA-1564112 Reactome:R-HSA-194796 Reactome:R-HSA-8942302 Reactome:R-HSA-420818 Reactome:R-HSA-2002440 Reactome:R-HSA-194793 MetaCyc:3.4.24.64-RXN MetaCyc:3.4.24.21-RXN Reactome:R-HSA-1251992 Reactome:R-HSA-2002428 Reactome:R-HSA-381537 MetaCyc:3.4.24.72-RXN MetaCyc:3.4.24.23-RXN Reactome:R-HSA-5250962 Reactome:R-HSA-5250606 MetaCyc:3.4.24.19-RXN Reactome:R-HSA-3791295 EC:3.4.24.- molecular_function Reactome:R-HSA-2485111 EC:3.4.24.3 EC:3.4.24.7 Reactome:R-HSA-1454757 Reactome:R-HSA-5250978 Reactome:R-HSA-2533874 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Reactome:R-HSA-1564120 Reactome:R-HSA-1458433 Reactome:R-HSA-1564117 EC:3.4.24.56 EC:3.4.24.55 EC:3.4.24.57 EC:3.4.24.59 Reactome:R-HSA-1474210 Reactome:R-HSA-1474213 Reactome:R-HSA-2473596 Reactome:R-HSA-2473594 Reactome:R-HSA-8949668 Reactome:R-HSA-3791149 EC:3.4.24.61 GO:0004222 Reactome:R-HSA-8867344 EC:3.4.24.65 EC:3.4.24.69 Reactome:R-HSA-2533970 Reactome:R-HSA-2473584 Reactome:R-HSA-5333671 Reactome:R-HSA-1564142 Reactome:R-HSA-8949659 Reactome:R-HSA-1564143 Reactome:R-HSA-8949649 Reactome:R-HSA-194800 EC:3.4.24.70 EC:3.4.24.72 EC:3.4.24.71 Reactome:R-HSA-3791155 MetaCyc:3.4.24.55-RXN Reactome:R-HSA-2533965 Reactome:R-HSA-8876868 Reactome:R-HSA-8874201 Reactome:R-HSA-9822532 Reactome:R-HSA-8940959 metallopeptidase activity