endopeptidase activity serine-type endopeptidase activity https://github.com/geneontology/go-ontology/issues/20581 https://github.com/geneontology/go-ontology/issues/30193 Reactome:R-HSA-1566962 Reactome:R-HSA-6807224 Reactome:R-HSA-381500 Reactome:R-HSA-159773 Reactome:R-HSA-159771 Reactome:R-HSA-8874212 Reactome:R-HSA-9919050 Reactome:R-HSA-1592436 Reactome:R-HSA-1592316 Reactome:R-HSA-1592314 Reactome:R-HSA-8874206 Reactome:R-HSA-8874205 Reactome:R-HSA-8874204 Reactome:R-HSA-8850831 Reactome:R-HSA-158333 Reactome:R-HSA-9918876 Reactome:R-HSA-9839367 Reactome:R-HSA-9829200 Reactome:R-HSA-9918871 Reactome:R-HSA-1604712 Reactome:R-HSA-3266557 Reactome:R-HSA-9926936 Reactome:R-HSA-158300 Reactome:R-HSA-9816275 Reactome:R-HSA-976743 Reactome:R-HSA-9909046 Reactome:R-HSA-9033520 Reactome:R-HSA-9909048 Reactome:R-HSA-2534206 Reactome:R-HSA-9655850 Reactome:R-HSA-2471621 Reactome:R-HSA-8849826 Reactome:R-HSA-9033515 Reactome:R-HSA-1604360 Reactome:R-HSA-9668365 Reactome:R-HSA-2514772 Reactome:R-HSA-1181152 Reactome:R-HSA-9921595 Reactome:R-HSA-166753 Reactome:R-HSA-1566981 Reactome:R-HSA-1604368 Reactome:R-HSA-5691512 Reactome:R-HSA-1566979 Reactome:R-HSA-140599 Reactome:R-HSA-9929060 Reactome:R-HSA-2482180 Reactome:R-HSA-8855825 Reactome:R-HSA-158313 Reactome:R-HSA-9033506 EC:3.4.21.10 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Reactome:R-HSA-9694661 Reactome:R-HSA-9668253 Reactome:R-HSA-1655842 Reactome:R-HSA-1912369 Reactome:R-HSA-9930792 Reactome:R-HSA-1799329 Reactome:R-HSA-9686710 Reactome:R-HSA-9930790 Reactome:R-HSA-2471842 Reactome:R-HSA-2534260 Reactome:R-HSA-9710263 blood coagulation factor activity Reactome:R-HSA-158925 Reactome:R-HSA-114697 Reactome:R-HSA-8865275 Reactome:R-HSA-173745 EC:3.4.21.102 Reactome:R-HSA-140840 Reactome:R-HSA-8865276 Reactome:R-HSA-6801687 Reactome:R-HSA-173626 Reactome:R-HSA-9033490 Reactome:R-HSA-1454843 Reactome:R-HSA-400459 Reactome:R-HSA-9930440 Reactome:R-HSA-158137 Reactome:R-HSA-1592362 Reactome:R-HSA-5578783 Reactome:R-HSA-141026 Reactome:R-HSA-381135 Reactome:R-HSA-9708859 Reactome:R-HSA-1604359 Reactome:R-HSA-9918795 Reactome:R-HSA-9911236 Reactome:R-HSA-159796 Reactome:R-HSA-140700 Reactome:R-HSA-163843 Reactome:R-HSA-9678434 Reactome:R-HSA-9686731 Reactome:R-HSA-166792 Reactome:R-HSA-9926963 Reactome:R-HSA-9699007 Reactome:R-HSA-1592371 Reactome:R-HSA-9918780 Reactome:R-HSA-9918787 Reactome:R-HSA-2214330 Reactome:R-HSA-9653249 Reactome:R-HSA-9822514 Reactome:R-HSA-9822513 Reactome:R-HSA-173631 Reactome:R-HSA-1912372 Reactome:R-HSA-9830805 Reactome:R-HSA-9927009 Reactome:R-HSA-9932162 Reactome:R-HSA-1604690 Reactome:R-HSA-9918772 Reactome:R-HSA-3244626 Reactome:R-HSA-6800200 Reactome:R-HSA-977371 Reactome:R-HSA-5210912 Reactome:R-HSA-140769 Reactome:R-HSA-381466 Reactome:R-HSA-1592270 Reactome:R-HSA-3788061 Reactome:R-HSA-158164 Reactome:R-HSA-9822522 EC:3.4.21.71 EC:3.4.21.73 EC:3.4.21.68 EC:3.4.21.69 molecular_function Reactome:R-HSA-381461 Reactome:R-HSA-1602488 Reactome:R-HSA-9710106 Reactome:R-HSA-139893 Reactome:R-HSA-1592278 Reactome:R-HSA-1602484 Reactome:R-HSA-9829030 Reactome:R-HSA-1592398 Reactome:R-HSA-9936906 Reactome:R-HSA-2168923 Reactome:R-HSA-9936467 Reactome:R-HSA-400496 Reactome:R-HSA-9769737 EC:3.4.21.83 Reactome:R-HSA-400492 EC:3.4.21.75 EC:3.4.21.78 EC:3.4.21.79 Reactome:R-HSA-2129357 Reactome:R-HSA-9912371 Reactome:R-HSA-187020 Reactome:R-HSA-5210935 Reactome:R-HSA-9670874 Reactome:R-HSA-9912368 Reactome:R-HSA-173680 Reactome:R-HSA-9673223 Reactome:R-HSA-3928657 Reactome:R-HSA-158942 EC:3.4.21.92 EC:3.4.21.93 EC:3.4.21.94 Reactome:R-HSA-9930452 Reactome:R-HSA-9662786 EC:3.4.21.88 Reactome:R-HSA-9936430 Reactome:R-HSA-1604763 Reactome:R-HSA-1592297 Reactome:R-HSA-1602466 Reactome:R-HSA-2534160 Reactome:R-HSA-8852716 Reactome:R-HSA-2514823 Reactome:R-HSA-8874186 Reactome:R-HSA-9857814 Reactome:R-HSA-2172405 Reactome:R-HSA-9913329 Reactome:R-HSA-3785684 Reactome:R-HSA-422021 Reactome:R-HSA-183122 Reactome:R-HSA-141040 serine elastase activity Reactome:R-HSA-9770187 Reactome:R-HSA-1474197 Reactome:R-HSA-9911383 Reactome:R-HSA-2022411 Reactome:R-HSA-140870 Reactome:R-HSA-9698988 Reactome:R-HSA-1602473 Reactome:R-HSA-170844 Reactome:R-HSA-9929051 Reactome:R-HSA-9023627 Reactome:R-HSA-9023626 Reactome:R-HSA-3814820 Reactome:R-HSA-174551 Reactome:R-HSA-6800198 Reactome:R-HSA-166817 Reactome:R-HSA-171288 GO:0004252 Reactome:R-HSA-977615 Reactome:R-HSA-158766 Reactome:R-HSA-265301 Reactome:R-HSA-159733 EC:3.4.21.9 EC:3.4.21.20 EC:3.4.21.21 EC:3.4.21.7 EC:3.4.21.22 EC:3.4.21.6 Reactome:R-HSA-5607002 EC:3.4.21.5 EC:3.4.21.4 Reactome:R-HSA-9023196 EC:3.4.21.26 Reactome:R-HSA-183130 EC:3.4.21.27 Reactome:R-HSA-1604741 EC:3.4.21.1 EC:3.4.21.- Reactome:R-HSA-9023633 Reactome:R-HSA-9023632 Reactome:R-HSA-1602458 Reactome:R-HSA-5591040 Reactome:R-HSA-9855735 Reactome:R-HSA-9655840 Reactome:R-HSA-2168960 Reactome:R-HSA-159868 Reactome:R-HSA-9033530 Reactome:R-HSA-9655046 EC:3.4.21.41 Reactome:R-HSA-9033529 Reactome:R-HSA-9921689 EC:3.4.21.34 EC:3.4.21.35 Reactome:R-HSA-382061 Reactome:R-HSA-158419 Reactome:R-HSA-9033524 EC:3.4.21.36 EC:3.4.21.38 EC:3.4.21.39 Reactome:R-HSA-1604752 Reactome:R-HSA-9694287 Reactome:R-HSA-140696 Reactome:R-HSA-9938539 Reactome:R-HSA-9918823 Reactome:R-HSA-381446 Reactome:R-HSA-158982 Reactome:R-HSA-158744 Reactome:R-HSA-9769949 Reactome:R-HSA-158747 EC:3.4.21.42 EC:3.4.21.43 Reactome:R-HSA-422051 EC:3.4.21.45 EC:3.4.21.46 EC:3.4.21.47 EC:3.4.21.48 Reactome:R-HSA-186785 Reactome:R-HSA-9830882 Reactome:R-HSA-9023178 Reactome:R-HSA-140664 Reactome:R-HSA-6800299 Reactome:R-HSA-9666383 Reactome:R-HSA-1604722 Reactome:R-HSA-9918813 Reactome:R-HSA-381798 Reactome:R-HSA-9918817 Reactome:R-HSA-158750 Reactome:R-HSA-9947496 Reactome:R-HSA-163798 EC:3.4.21.61 EC:3.4.21.62 Reactome:R-HSA-8874145 EC:3.4.21.53 EC:3.4.21.54 Reactome:R-HSA-159728 EC:3.4.21.59 Reactome:R-HSA-8849857 Reactome:R-HSA-1604732 Reactome:R-HSA-1604731 serine-type peptidase activity