estradiol 17-beta-dehydrogenase [NAD(P)+] activity https://github.com/geneontology/go-ontology/issues/19811 https://github.com/geneontology/go-ontology/issues/21791 https://github.com/geneontology/go-ontology/issues/30193 Reactome:R-HSA-5696822 17-beta-hydroxysteroid dehydrogenase activity 20alpha-hydroxysteroid dehydrogenase GO:0004303 estradiol 17beta-dehydrogenase activity RHEA:24616 RHEA:24612 MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN estrogen 17-oxidoreductase activity 17beta-HSD molecular_function estradiol dehydrogenase activity estradiol-17beta:NAD(P)+ 17-oxidoreductase activity 17beta-hydroxysteroid dehydrogenase activity 17-beta-estradiol dehydrogenase activity 17beta-estradiol dehydrogenase activity Reactome:R-HSA-8862137 Reactome:R-HSA-6810594 17beta,20alpha-hydroxysteroid dehydrogenase activity Reactome:R-HSA-5693390 17-beta-HSD activity estradiol 17-beta-dehydrogenase activity Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. EC:1.1.1.62 Reactome:R-HSA-804969 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor