iodide peroxidase activity https://github.com/geneontology/go-ontology/issues/21027 https://github.com/geneontology/go-ontology/issues/23587 https://github.com/geneontology/go-ontology/issues/30193 https://github.com/geneontology/go-ontology/issues/30597 thyroperoxidase activity molecular_function RHEA:23336 thyroid peroxidase activity GO:0004447 TPO activity iodinase activity RHEA:48960 MetaCyc:IODIDE-PEROXIDASE-RXN RHEA:48964 RHEA:48968 EC:1.11.1.8 Catalysis of the reactions: (1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O; (2) [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O; (3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O; (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-dehydroalanine + 2 H2O; (5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O. RHEA:48956 haloperoxidase activity