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    <!-- http://purl.obolibrary.org/obo/GO_0004489 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0004489">
        <rdfs:label>methylenetetrahydrofolate reductase [NAD(P)H] activity</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0016646"/>
        <ns3:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/30193</ns3:IAO_0000233>
        <oboInOwl:hasExactSynonym>5,10-methylenetetrahydrofolate reductase (FADH2) activity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>5,10-methylenetetrahydrofolate reductase (FADH) activity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>N5,10-methylenetetrahydrofolate reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasOBONamespace>molecular_function</oboInOwl:hasOBONamespace>
        <ns3:IAO_0000115>Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.</ns3:IAO_0000115>
        <oboInOwl:hasBroadSynonym>5,10-methylenetetrahydrofolic acid reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasRelatedSynonym>methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>methylenetetrahydrofolate reductase (NADPH2)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>methylenetetrahydrofolate reductase [NAD(P)H]</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NAD oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NAD+ oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>N5,N10-methylenetetrahydrofolate reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasBroadSynonym>methylenetetrahydrofolic acid reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasRelatedSynonym>MetF</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>MetaCyc:1.5.1.20-RXN</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>5,10-CH2-H4folate reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasBroadSynonym>methylenetetrahydrofolate reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:(acceptor) oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>methylenetetrahydrofolate reductase (NADPH(2)) activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5,10-CH(2)-H(4)folate reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Reactome:R-HSA-200676</oboInOwl:hasDbXref>
        <oboInOwl:hasBroadSynonym>5,10-methylenetetrahydrofolate reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>KEGG_REACTION:R07168</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG_REACTION:R01224</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>5,10-methylenetetrahydropteroylglutamate reductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5,10-methylenetetrahydrofolate reductase (NADPH) activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>GO:0008702</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>EC:1.5.1.20</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NADP+ oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0004489</oboInOwl:id>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NAD(+) oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasBroadSynonym>N(5,10)-methylenetetrahydrofolate reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasBroadSynonym>MTHFR activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasBroadSynonym>N(5),N(10)-methylenetetrahydrofolate reductase activity</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasRelatedSynonym>5-methyltetrahydrofolate:NADP(+) oxidoreductase activity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>5,10-methylenetetrahydrofolate reductase (FADH(2)) activity</oboInOwl:hasRelatedSynonym>
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    <!-- http://purl.obolibrary.org/obo/GO_0016646 -->

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        <rdfs:label>oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor</rdfs:label>
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