steroid 17-alpha-monooxygenase activity https://github.com/geneontology/go-ontology/issues/27671 https://github.com/geneontology/go-ontology/issues/28526 https://github.com/geneontology/go-ontology/issues/29041 steroid 17-alpha-hydroxylase-C17-20 lyase activity Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. EC:1.14.14.19 MetaCyc:4.1.2.30-RXN Reactome:R-HSA-193070 steroid 17-alpha-hydroxylase/17,20 lyase activity Reactome:R-HSA-193072 steroid 17alphahydroxylase/17,20 lyase activity RHEA:50244 steroid 17-alpha-hydroxylase activity RHEA:46308 RHEA:65760 molecular_function steroid 17alpha-hydroxylase activity cytochrome P45017alpha EC:1.14.14.32 MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN 17alpha-hydroxylase-C17,20 lyase activity steroid 17alpha-monooxygenase activity cytochrome P450 CYP17 cytochrome p450 XVIIA1 activity RHEA:14753 RHEA:84243 steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) Reactome:R-HSA-193099 Reactome:R-HSA-9035956 cytochrome P-450 (P-45017alpha,lyase) Reactome:R-HSA-9035954 RHEA:50236 Reactome:R-HSA-5601843 Reactome:R-HSA-193068 GO:0004508 steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen