RNA-DNA hybrid ribonuclease activity https://github.com/geneontology/go-ontology/issues/30193 hybridase activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. RNase H1 activity ribonuclease H3 activity endoribonuclease H (calf thymus) RNase H activity endoribonuclease0 H activity RNA*DNA hybrid ribonucleotidohydrolase activity RNase H2 activity hybrid ribonuclease activity Reactome:R-HSA-9914858 Reactome:R-HSA-182795 Reactome:R-HSA-9915449 Reactome:R-HSA-164528 ribonuclease H activity EC:3.1.26.4 MetaCyc:3.1.26.4-RXN ribonuclease H2 activity hybridase (ribonuclease H) Reactome:R-HSA-182859 Reactome:R-HSA-173769 ribonuclease H1 activity GO:0004523 calf thymus ribonuclease H activity Reactome:R-HSA-164519 endoribonuclease H RNase H3 activity Reactome:R-HSA-9913637 molecular_function GO:0004524 hybrid nuclease activity Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism