protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity https://github.com/geneontology/go-ontology/issues/29095 PDH kinase activity MetaCyc:2.7.11.2-RXN pyruvate dehydrogenase kinase (phosphorylating) activity Reactome:R-HSA-203946 PDK RHEA:23052 pyruvate dehydrogenase kinase activity GO:0004740 Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]. EC:2.7.11.2 molecular_function PDHK