ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor https://github.com/geneontology/go-ontology/issues/30193 When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. GO:0004748 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity Reactome:R-HSA-111804 Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN Reactome:R-HSA-111751 molecular_function RHEA:28030 GO:0016959 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity RHEA:23252 RHEA:28038 EC:1.17.4.1 GO:0016961 GO:0016960 ribonucleoside-diphosphate reductase activity