part of DNA-binding transcription factor activity, RNA polymerase II-specific nuclear receptor activity https://github.com/geneontology/go-ontology/issues/19518 https://github.com/geneontology/go-ontology/issues/20253 https://github.com/geneontology/go-ontology/issues/29150 Reactome:R-HSA-400143 RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding vitamin D3 receptor activity glucocorticoid receptor activity ligand-dependent transcription factor activity Reactome:R-HSA-8937169 ligand-dependent nuclear receptor activity calcitriol receptor activity ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. retinoic acid receptor activity juvenile hormone receptor activity vitamin A receptor activity androgen receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. estrogen nuclear receptor activity Reactome:R-HSA-8936849 nuclear hormone receptor GO:0038050 GO:0038051 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0038052 thyroid hormone receptor activity GO:0008434 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding RXR GO:0004879 ecdysteroid hormone receptor activity GO:0003708 Reactome:R-HSA-8937191 vitamin D receptor activity retinoid-X receptor activity GO:0004886 molecular_function GO:0004887 9-cis retinoic acid receptor activity GO:0004884 1,25-(OH)2D3 receptor activity GO:0004882 GO:0004880 intracellular receptor signaling pathway signaling receptor activity ligand-modulated transcription factor activity