cell adhesion receptor activity https://github.com/geneontology/go-ontology/issues/15237 Reinstated term from obsolete. molecular_function The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins. GO:0004895 signaling receptor activity cell adhesion mediator activity