negatively regulates positively regulates guanyl-nucleotide exchange factor activity https://github.com/geneontology/go-ontology/issues/18749 https://github.com/geneontology/go-ontology/issues/18750 https://github.com/geneontology/go-ontology/issues/27684 Reactome:R-HSA-1433415 Reactome:R-HSA-2029451 Reactome:R-HSA-5655241 Reactome:R-HSA-5654392 Reactome:R-HSA-1250463 Reactome:R-HSA-9693111 Reactome:R-HSA-8877760 Reactome:R-HSA-9013159 Reactome:R-HSA-5218839 Reactome:R-HSA-8982640 Reactome:R-HSA-3928642 Reactome:R-HSA-9703441 Reactome:R-HSA-2029467 Reactome:R-HSA-8982637 Reactome:R-HSA-5218829 Reactome:R-HSA-399995 GO:0016219 RhoGEF Reactome:R-HSA-442732 GO:0016220 Reactome:R-HSA-9029158 Reactome:R-HSA-9665009 Reactome:R-HSA-8980691 Reactome:R-HSA-3928651 Reactome:R-HSA-8877998 Reactome:R-HSA-2485180 GO:0019839 Reactome:R-HSA-1225951 Reactome:R-HSA-428917 Reactome:R-HSA-169904 GO:0005085 Reactome:R-HSA-1225957 Reactome:R-HSA-3965444 Reactome:R-HSA-5218850 Reactome:R-HSA-420883 Reactome:R-HSA-2424476 Reactome:R-HSA-2424477 Reactome:R-HSA-9018747 Reactome:R-HSA-6811418 Reactome:R-HSA-9032798 Reactome:R-HSA-442291 Reactome:R-HSA-8875320 Reactome:R-HSA-6811414 Reactome:R-HSA-9634418 Reactome:R-HSA-8875568 Reactome:R-HSA-5654618 Reactome:R-HSA-2029445 Reactome:R-HSA-8875318 Reactome:R-HSA-9619803 Reactome:R-HSA-5654600 Reactome:R-HSA-418579 Reactome:R-HSA-5686318 Reactome:R-HSA-9624845 Reactome:R-HSA-9665707 Reactome:R-HSA-9665700 Reactome:R-HSA-1250498 Reactome:R-HSA-6811429 Reactome:R-HSA-9680385 Reactome:R-HSA-8877612 Reactome:R-HSA-5655326 GEF Reactome:R-HSA-2179407 Reactome:R-HSA-9695853 GO:0030676 Reactome:R-HSA-9018804 Reactome:R-HSA-442273 Reactome:R-HSA-400037 Reactome:R-HSA-1250383 Reactome:R-HSA-9660824 Reactome:R-HSA-751029 Reactome:R-HSA-109807 Rho guanyl-nucleotide exchange factor activity Reactome:R-HSA-194518 Reactome:R-HSA-5637806 Reactome:R-HSA-9664991 Reactome:R-HSA-5623521 Reactome:R-HSA-1168636 GO:0017112 Reactome:R-HSA-9018817 GDP-dissociation stimulator activity Reactome:R-HSA-5637808 Reactome:R-HSA-8877311 Reactome:R-HSA-5655347 Reactome:R-HSA-3928612 Reactome:R-HSA-8877308 Reactome:R-HSA-210977 GNRP Reactome:R-HSA-354173 Ral guanyl-nucleotide exchange factor activity Reactome:R-HSA-9670436 Reactome:R-HSA-205039 Reactome:R-HSA-9018825 Reactome:R-HSA-8850041 Reactome:R-HSA-156913 Reactome:R-HSA-8876454 Reactome:R-HSA-180687 Reactome:R-HSA-9672170 Reactome:R-HSA-5686071 ARF guanyl-nucleotide exchange factor activity Reactome:R-HSA-9013023 Reactome:R-HSA-9013143 Reactome:R-HSA-8851827 Reactome:R-HSA-5623508 Reactome:R-HSA-3928628 Reactome:R-HSA-1306972 Rho guanine nucleotide exchange factor Reactome:R-HSA-2730840 Reactome:R-HSA-9970163 Reactome:R-HSA-9672163 Reactome:R-HSA-8875591 Reactome:R-HSA-3928632 Reactome:R-HSA-3928633 Reactome:R-HSA-939265 Reactome:R-HSA-8876837 Reactome:R-HSA-4093336 cAMP-dependent guanyl-nucleotide exchange factor activity Reactome:R-HSA-177945 Reactome:R-HSA-9751201 Reactome:R-HSA-445064 Rap guanyl-nucleotide exchange factor activity Reactome:R-HSA-9013435 Reactome:R-HSA-416530 Reactome:R-HSA-5654426 Reactome:R-HSA-5654663 Reactome:R-HSA-5694409 Rab guanyl-nucleotide exchange factor activity Rac guanyl-nucleotide exchange factor activity Reactome:R-HSA-177938 GO:0008321 GO:0017034 Reactome:R-HSA-9665408 Reactome:R-HSA-428750 Reactome:R-HSA-187746 Reactome:R-HSA-9665404 Reactome:R-HSA-8877475 Reactome:R-HSA-8964604 Reactome:R-HSA-109817 Reactome:R-HSA-9017491 Reactome:R-HSA-171026 Reactome:R-HSA-1433471 GO:0008433 Reactome:R-HSA-170979 Reactome:R-HSA-400092 Reactome:R-HSA-418850 Reactome:R-HSA-9014433 Reactome:R-HSA-5617816 Reactome:R-HSA-379048 GDS Reactome:R-HSA-379044 Reactome:R-HSA-418856 Reactome:R-HSA-203977 Reactome:R-HSA-442314 GO:0017132 Reactome:R-HSA-9607304 Reactome:R-HSA-8848618 Reactome:R-HSA-8877451 Reactome:R-HSA-428535 Reactome:R-HSA-9013109 Reactome:R-HSA-8851877 Reactome:R-HSA-5672965 Reactome:R-HSA-392195 Reactome:R-HSA-389348 Reactome:R-HSA-6807868 Reactome:R-HSA-114544 Reactome:R-HSA-9639286 Reactome:R-HSA-389350 Reactome:R-HSA-399938 Reactome:R-HSA-9026891 Reactome:R-HSA-8876193 Reactome:R-HSA-9018768 Reactome:R-HSA-9014296 Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. Reactome:R-HSA-825631 Reactome:R-HSA-9033292 Ran guanyl-nucleotide exchange factor activity GO:0005090 Reactome:R-HSA-419166 Sar guanyl-nucleotide exchange factor activity molecular_function Reactome:R-HSA-8876190 Reactome:R-HSA-5655277 Reactome:R-HSA-8876191 guanyl-nucleotide releasing factor Reactome:R-HSA-8876188 Reactome:R-HSA-392870 Reactome:R-HSA-8851899 GO:0005086 Reactome:R-HSA-8876615 Reactome:R-HSA-8876616 Reactome:R-HSA-381727 Reactome:R-HSA-5654413 GO:0005089 GO:0005088 GO:0005087 Reactome:R-HSA-416588 Reactome:R-HSA-9666428 Reactome:R-HSA-350769 Reactome:R-HSA-5654647 Ras guanyl-nucleotide exchange factor activity Reactome:R-HSA-9036301 guanyl-nucleotide release factor activity Reactome:R-HSA-5654402 Reactome:R-HSA-9640167 Reactome:R-HSA-9666430 Reactome:R-HSA-186834 Reactome:R-HSA-3928592 Reactome:R-HSA-380073 Reactome:R-HSA-392054 Reactome:R-HSA-8877813 Reactome:R-HSA-9032067 Reactome:R-HSA-749453 GTP binding GDP binding GTPase regulator activity