chloride channel activity intracellularly ATP-gated chloride channel activity https://github.com/geneontology/go-ontology/issues/14402 https://github.com/geneontology/go-ontology/issues/29690 https://github.com/geneontology/go-ontology/issues/30193 https://github.com/geneontology/go-ontology/issues/30980 CFTR TC:3.A.1.202.1 Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator). MetaCyc:3.6.3.49-RXN GO:0005260 EC:5.6.1.6 molecular_function GO:0005224 Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. cystic fibrosis transmembrane conductance regulator channel-conductance-controlling ATPase activity ligand-gated monoatomic anion channel activity intracellularly ATP-gated ion channel activity polypeptide conformation or assembly isomerase activity