part of has part origin recognition complex nucleoplasm nuclear pre-replicative complex pre-RC A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. eukaryotic pre-replicative complex pre-replicative complex cellular_component GO:0005656 pre-replicative complex MCM complex nuclear protein-containing complex