part of has part dihydrolipoyl dehydrogenase (NADH) activity pyruvate dehydrogenase (acetyl-transferring) activity dihydrolipoyllysine-residue acetyltransferase activity acetyl-CoA biosynthetic process pyruvate decarboxylation to acetyl-CoA https://github.com/geneontology/go-ontology/issues/24348 https://github.com/geneontology/go-ontology/issues/30067 https://github.com/geneontology/go-ontology/issues/30126 https://github.com/geneontology/go-ontology/issues/31634 pyruvate decarboxylation biological_process MetaCyc:PWY-8275 Reactome:R-HSA-9861559 acetyl-CoA anabolism from pyruvate acetyl-CoA biosynthetic process from pyruvate acetyl-CoA synthesis from pyruvate oxidative decarboxylation of pyruvate pyruvate dehydrogenase pathway acetyl-CoA formation from pyruvate MetaCyc:PWY-6970 MetaCyc:PYRUVDEHYD-PWY The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH. GO:0006086 pyruvate metabolic process aerobic respiration