7-methylguanosine mRNA capping mRNA capping 5' end capping The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively. Reactome:R-HSA-72086 5'-end mRNA processing GO:0006370 biological_process 5'-end processing 5' mRNA capping mRNA processing 7-methylguanosine RNA capping