obsolete activation of signaling protein activity involved in unfolded protein response true The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response. unfolded protein response, activation of signalling protein kinase/endonuclease biological_process unfolded protein response, activation of signaling protein kinase/endonuclease GO:0006987 unfolded protein response, activation of signaling protein activity IRE1-mediated unfolded protein response