has part G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway https://github.com/geneontology/go-ontology/issues/28414 G-protein signalling, coupled to IP3 second messenger (phospholipase C activating) protein kinase C-activating G protein-coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to IP3 second messenger A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) G protein signaling, coupled to IP3 second messenger (phospholipase C activating) biological_process phospholipase C-activating G-protein coupled receptor signaling pathway G protein signalling, coupled to IP3 second messenger (phospholipase C activating) PLC-activating GPCR signaling pathway GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger phospholipase C activator activity