MAPK cascade JNK cascade https://github.com/geneontology/go-ontology/issues/26806 c-Jun N-terminal kinase cascade JNK3 cascade MAPK9 cascade Reactome:R-HSA-450321 stress-activated protein kinase cascade biological_process MAPK8 cascade MAPK10 cascade A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. SAPK cascade JNK2 cascade GO:0007254 JNK1 cascade