N-acetyllactosaminide alpha-2,3-sialyltransferase activity https://github.com/geneontology/go-ontology/issues/28444 https://github.com/geneontology/go-ontology/issues/30193 RHEA:80751 neolactotetraosylceramide alpha-2,3-sialyltransferase activity RHEA:65432 RHEA:80755 GO:0008118 MetaCyc:2.4.99.6-RXN cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity N-acetyllactosaminide alpha-2,3-sialyltransferase RHEA:56264 RHEA:18913 Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H+. RHEA:52316 EC:2.4.3.6 The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. alpha2->3 sialyltransferase activity molecular_function sialyltransferase activity