part of protein serine/threonine kinase activity I-kappaB phosphorylation IkappaB kinase activity https://github.com/geneontology/go-ontology/issues/30193 IKK-2 IKK-1 Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. molecular_function Reactome:R-HSA-5684275 Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. inhibitor of NFkappaB kinase activity RHEA:19073 CHUK TBK1 Reactome:R-HSA-5684267 IKBKA inhibitor of NF-kappaB kinase activity IKBKB ATP:IkappaB protein phosphotransferase activity STK12 GO:0008384 IKK TANK-binding kinase 1 activity MetaCyc:2.7.11.10-RXN EC:2.7.11.10