part of ubiquinone biosynthetic process C-methyltransferase activity 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity https://github.com/geneontology/go-ontology/issues/25591 https://github.com/geneontology/go-ontology/issues/25682 https://github.com/geneontology/go-ontology/issues/29420 https://github.com/geneontology/go-ontology/issues/30193 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity RHEA:27774 coenzyme Q biosynthesis methyltransferase activity GO:0008425 RHEA:28286 2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity RHEA:44756 Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. ubiquinone biosynthetic process methyltransferase activity Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. RHEA:44752 EC:2.1.1.201 ubiquinone biosynthesis methyltransferase activity molecular_function coenzyme Q biosynthetic process methyltransferase activity Reactome:R-HSA-2162188 RHEA:44760 RHEA:44764