fatty acid elongase activity https://github.com/geneontology/go-ontology/issues/24752 https://github.com/geneontology/go-ontology/issues/25805 https://github.com/geneontology/go-ontology/issues/30193 RHEA:37243 elongation of very long chain fatty acids activity Reactome:R-HSA-548800 RHEA:36875 GO:0009922 RHEA:36911 RHEA:36515 RHEA:36871 very-long-chain 3-ketoacyl-CoA synthase RHEA:36995 RHEA:36919 RHEA:36519 RHEA:36915 Reactome:R-HSA-548815 RHEA:36943 molecular_function Reactome:R-HSA-548814 RHEA:36983 Reactome:R-HSA-2046100 RHEA:36907 RHEA:36947 very-long-chain beta-ketoacyl-CoA synthase RHEA:36531 RHEA:36851 Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. RHEA:36819 ELOVL RHEA:36979 RHEA:36859 Reactome:R-HSA-2046095 Reactome:R-HSA-2046094 EC:2.3.1.199 Reactome:R-HSA-2046090 RHEA:39291 condensing enzyme RHEA:37095 RHEA:85827 RHEA:36963 RHEA:36843 Reactome:R-HSA-548830 RHEA:36927 RHEA:32727 RHEA:36807 Reactome:R-HSA-2046088 RHEA:36923 RHEA:36967 Reactome:R-HSA-2046083 very-long-chain 3-oxoacyl-CoA synthase MetaCyc:RXN-7697 acyltransferase activity, transferring groups other than amino-acyl groups