positively regulates cell communication by chemical coupling regulation of cell communication by chemical coupling positive regulation of cell communication positive regulation of cell communication by chemical coupling Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. biological_process GO:0010652 biological regulation