negatively regulates cell communication by chemical coupling regulation of cell communication by chemical coupling negative regulation of cell communication negative regulation of cell communication by chemical coupling Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. GO:0010653 biological_process biological regulation