adenylate cyclase-activating G protein-coupled receptor signaling pathway obsolete protein kinase A signaling https://github.com/geneontology/go-ontology/issues/26794 https://github.com/geneontology/go-ontology/issues/26899 true PKA signaling cascade This term was obsoleted because it does not represent a specific pathway. Consider cAMP/PKA signal transduction ; GO:0141156 or adenylate cyclase-activating G protein-coupled receptor signaling pathway ; GO:0007189. GO:0010737 protein kinase A signalling cascade biological_process protein kinase A signal transduction OBSOLETE. An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C. protein kinase A signaling cascade cAMP/PKA signal transduction