regulates nitric oxide mediated signal transduction regulation of nitric oxide mediated signal transduction Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). biological_process GO:0010749 regulation of nitric oxide-mediated signal transduction biological regulation regulation of intracellular signal transduction