RISC complex miRNP complex RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. micro-ribonucleoprotein complex Wikipedia:RNA-induced_silencing_complex GO:0016442 GO:0035068 cellular_component RNAi effector complex