acid-ammonia (or amide) ligase activity lipoate-protein ligase activity https://github.com/geneontology/go-ontology/issues/28526 https://github.com/geneontology/go-ontology/issues/31616 molecular_function GO:0102315 Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. GO:0016978 GO:0016979 lipoate-protein ligase B activity GO:0008916 lipoate-protein ligase activity (lipoylation of glycine cleavage complex) EC:6.3.1.20 MetaCyc:RXN0-5098 MetaCyc:RXN-17127 RHEA:49288 lipoate-protein ligase A activity MetaCyc:RXN0-1141 catalytic activity, acting on a protein