part of lipoate biosynthetic process sulfurtransferase activity lipoate synthase activity https://github.com/geneontology/go-ontology/issues/28526 https://github.com/geneontology/go-ontology/issues/30187 LS MetaCyc:RXN-14959 protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity MetaCyc:RXN-14957 MetaCyc:RXN-14950 RHEA:16585 GO:0016992 LipA GO:0017140 EC:2.8.1.8 molecular_function MetaCyc:RXN0-949 lipoyl synthase activity protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]. lipoic acid synthase Reactome:R-HSA-6793591