SCF ubiquitin ligase complex GO:0019005 SCF complex substrate recognition subunit SCF complex CDL1 complex cullin-RING ligase 1 cellular_component Cul1-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). CRL1 complex Skp1/Cul1/F-box protein complex Wikipedia:SCF_complex cullin-RING ubiquitin ligase complex