cell-substrate junction hemidesmosome Wikipedia:Hemidesmosome GO:0030056 fibrous organelle A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces. cellular_component hemi-adherens junction epidermal attachment structure trans-epithelial attachment