endoplasmic reticulum membrane obsolete integral component of endoplasmic reticulum membrane https://github.com/geneontology/go-ontology/issues/23424 true OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. This term was obsoleted because it represents protein topology, not a cellular component. GO:0030176 ER integral membrane protein cellular_component integral to endoplasmic reticulum membrane integral to ER membrane