oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [methionine synthase] reductase (NADPH) activity https://github.com/geneontology/go-ontology/issues/28557 https://github.com/geneontology/go-ontology/issues/30193 RHEA:23908 GO:0030586 methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity RHEA:20752 EC:1.16.1.8 methionine synthase reductase activity MetaCyc:2.1.1.135-RXN methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing) Reactome:R-HSA-3149518 molecular_function methionine synthase cob(II)alamin reductase (methylating) activity [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.