part of retromer complex retromer, cargo-selective complex cellular_component retromer, CRC The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. retromer CSC GO:0030906 retromer complex, inner shell retromer, cargo recognition complex cargo-selective retromer subcomplex membrane protein complex