microtubule cytoskeleton organization cytoplasmic microtubule organization cytoplasmic microtubule organisation A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. biological_process GO:0031122 cytoplasmic microtubule organization and biogenesis supramolecular fiber organization