anaphase-promoting complex-dependent catabolic process APC-dependent proteasomal ubiquitin-dependent protein catabolism anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation cyclin breakdown GO:0031145 cyclin catabolic process anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism APC-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0008054 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process cyclin degradation Reactome:R-HSA-174048 Reactome:R-HSA-174143 Reactome:R-HSA-174154 degradation of cyclin anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown Reactome:R-HSA-174184 cyclin catabolism proteasome-mediated ubiquitin-dependent protein catabolic process