TRAMP complex Wikipedia:TRAMP_complex GO:0031499 Trf4 poly(A) polymerase complex Trf4p-Air2p-Mtr4p polyadenylation complex TRAMP4 complex Trf4 complex A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. TRAMP5 complex cellular_component nuclear protein-containing complex