endoplasmic reticulum to Golgi vesicle-mediated transport retrograde protein transport, ER to cytosol obsolete protein exit from endoplasmic reticulum https://github.com/geneontology/go-ontology/issues/19122 true biological_process GO:0032527 The reason for obsoletion is that this term conflated multiple distinct processes (retrograde transport from ER to cytosol, transmembrane transport of small molecules, and COPII-vesicle-mediated trafficking) and was used inconsistently. For COPII-vesicle-mediated forward transport from the ER, consider GO:0090114 'COPII-coated vesicle budding' or GO:0006888 'endoplasmic reticulum to Golgi vesicle-mediated transport'. For retrograde transport of misfolded proteins from ER to cytosol, consider GO:0030970 'retrograde protein transport, ER to cytosol'. OBSOLETE. The directed movement of proteins from the endoplasmic reticulum. COPII-coated vesicle budding