protein-containing complex CAF-1 complex In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90. A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. chromatin assembly factor 1 complex GO:0033186 cellular_component