amyloid-beta formation The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000). beta-amyloid formation biological_process beta-amyloid polypeptide formation from amyloid precursor protein GO:0034205 beta-amyloid polypeptide formation from APP amyloid precursor protein catabolic process amyloid-beta metabolic process