transcription coactivator activity nuclear receptor activity regulation of transcription by RNA polymerase II intracellular receptor signaling pathway obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor true This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand. biological_process GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter.