'de novo' NAD+ biosynthetic process from L-tryptophan obsolete 'de novo' NAD biosynthetic process https://github.com/geneontology/go-ontology/issues/29050 true This term was obsoleted because it is an unnecessary grouping term. OBSOLETE. The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD+, or the reduced form, NADH. biological_process de novo NAD biosynthetic process GO:0034627 'de novo' NAD+ biosynthetic process from L-aspartate