regulatory ncRNA-mediated post-transcriptional gene silencing miRNA-mediated post-transcriptional gene silencing https://github.com/geneontology/go-ontology/issues/22860 biological_process Reactome:R-HSA-9759811 gene silencing by miRNA miRNA-mediated gene silencing A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. microRNA-mediated gene silencing GO:0035195 gene silencing by microRNA