(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity https://github.com/geneontology/go-ontology/issues/26445 RHEA:78927 very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). bf Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. molecular_function GO:0035380 very long-chain-3-hydroxyacyl-CoA dehydrogenase activity 2010-03-18T11:23:05Z