2-oxoglutarate-dependent dioxygenase activity DNA demethylase activity broad specificity oxidative DNA demethylase activity https://github.com/geneontology/go-ontology/issues/21159 https://github.com/geneontology/go-ontology/issues/30193 5-formylcytosine dioxygenase activity 5hmC dioxygenase RHEA:70439 RHEA:30299 molecular_function GO:0035516 Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. EC:1.14.11.33 N3-methylcytosine demethylase activity Reactome:R-HSA-112118 RHEA:70447 1-ethyladenine demethylase activity RHEA:70443 2010-04-30T02:38:16Z bf MetaCyc:RXN-12353 N1-methyladenine demethylase activity Reactome:R-HSA-112123 oxidative DNA demethylase activity This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. GO:0103051 5-hydroxymethylcytosine dioxygenase activity GO:0103052 GO:0103053 2-oxoglutarate-dependent DNA demethylase 5fC dioxygenase RHEA:70435