8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity https://github.com/geneontology/go-ontology/issues/30193 8-oxo-dGTPase activity 8-oxo-dGTP pyrophosphohydrolase activity molecular_function EC:3.6.1.55 2010-05-07T10:54:19Z Reactome:R-HSA-2395869 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity Reactome:R-HSA-2395849 RHEA:31575 Reactome:R-HSA-9750555 Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity bf nucleoside triphosphate diphosphatase activity