autophagy of mitochondrion mitophagy by internal vacuole formation https://github.com/geneontology/go-ontology/issues/25541 GO:0035695 The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes. bf 2011-02-28T03:01:04Z MIV-mediated mitophagy In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome. biological_process