cytoplasmic pattern recognition receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway NLR signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway biological_process nucleotide-binding domain, leucine rich repeat containing receptor signal transduction The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. bf Reactome:R-HSA-168643 GO:0035872 NOD-like receptor signaling pathway 2011-05-26T03:30:36Z