methyltransferase complex RNA N6-methyladenosine methyltransferase complex cellular_component 2013-07-15T10:17:50Z METTL3-METTL14-WTAP methyltransferase complex GO:0036396 bf WMM complex MIS complex m(6)A writer complex A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). Mum2, Ime4, and Slz1 complex m6A methyltransferase complex